Abstract. Drug interactions with digoxin are important because of this agent's narrow therapeutic index. Among the drugs that can decrease. medications are known to interact with digoxin. Includes tramadol, lisinopril, trazodone. Because digoxin in used so commonly, awareness of drug interactions by patients and caregivers is essential to patient safety. With careful.
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Macrolides include erythromycin, clarithromycin and azithromycin.
Drugs That Interact With Digoxin
In a year study digoxin drug interactions in the Clinical Pharmacology and Therapeutics Journal in Octoberwhich observed use of these macrolide antibiotics with digoxin, drug interaction and toxicity identified by hospital admission were greatly associated with clarithromycin use.
Lesser associations were observed for erythromycin and azithromycin, and no toxicity or interaction digoxin drug interactions observed with digoxin and cephalosporin antibiotic use.
Talk to your doctor if you are pregnant or might become pregnant before taking this medication. Digoxin has been found to pass into breast milk, so talk to your doctor if you are breastfeeding or plan to breastfeed.
Digoxin | Interactions | BNF Provided by NICE
This effect is dependent on concentrations of amiodarone; the greater the concentration of amiodarone the greater the increase in serum digoxin levels. August Explanation The use of the digoxin drug interactions glycoside, digoxin Digitek; Lanoxin is common in the treatment of symptomatic heart failure HF as well as in patients with atrial arrhythmias in digoxin drug interactions ventricular rate control.
Some coadministered drugs such as macrolides and cardiovascular drugs especially amiodarone can cause digoxin overdose through pharmacokinetic interactions.
The mechanism most often implicated is inhibition of P-glycoprotein, of which digoxin is a substrate. Hypercalcaemia and hypokalaemia digoxin drug interactions drugs, heart-rate lowering drugs, and drugs that prolong the QT interval or slow cardiac conduction can potentiate the cardiac adverse effects of digoxin.
Usually avoid combinations; use it only under special circumstances. Minor Minimally clinically significant.