Acta Biochimica et Biophysica Sinica, Volume 42, Issue 11, 1 November , Pages –, Acta Biochimica Polonica, 61(3), , Review . Lipari G, Szabo A Model-free approach to the interpretation of nuclear magnetic resonance. Dottorato di ricerca in Biochimica e. Biologia Cellulare e 23 Fendly BM, Winget M, Hudziak RM, Lipari MT, Napier MA, Ullrich A. Characterization of.
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Direct and indirect evidence strongly indicated that intimal hyperplasia or proliferation of medial smooth muscle cells may be one of the main reasons [ 1 ]. Medial vascular smooth muscle cells VSMCs constitute the cardinal component of the arterial wall.
It is believed that restenosis involves the reactivation of quiescent VSMCs in the arterial wall that induced by mechanical or inflammatory means [ 2 ]. The proliferation of VSMCs is controlled by a complex interaction between stimulatory and inhibitory growth factors [ 3 ].
When the stimulating growth factors overcome the action of inhibitors, the proliferative activity of VSMCs is greatly increased and the healing process occurs [ 45 ]. The intrinsic proliferative potential of VSMCs may lipari biochimica play an important role in the growth regulation.
Currently, treatments for restenosis have focused on the conventional medicine, gene therapy, interventional therapy, and surgical procedures. These treatments can reduce the risk of restenosis to a certain extent, but their effects on the repair of vascular endothelium and the inhibition of neointimal hyperplasia in the injured vascular are incompletely understood.
Endogenous electric fields EFs are present in physiological and lipari biochimica processes such as the wound healing, tissue regeneration, embryonic development, and tumor formation [ 6 ].
They also exist around blood vessels. Researchers have discovered that there are several types of electric potential difference around the vascular endothelium and that lipari biochimica fields are critical in regulation of the generation and development of thrombosis [ 7 ].
Electric potential difference can be generated when the vascular endothelium is injured [ 7 ]. The electric current generated at the wound area and the surrounding epithelial area is a steady direct current DC [ 8 ].
These endogenous EFs exert biological effects on promoting the wound healing by facilitating cell division, cell proliferation, cell directional migration toward the wound, and by remodeling and stimulating the release of various cytokines and growth factors such as vascular endothelial growth factor [ 9 ].
If endogenous EFs cannot stimulate the wound healing, the application of DC to the injured and the non-injured regions could greatly benefit this process.
It has been confirmed that the healing of bone fractures, chronic injuries to the soft tissue, intractable skin ulcers, as well as many other traumatic disorders can lipari biochimica improved or even treated by application of steady-DC EFs [ 10 ].
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lipari biochimica For example, the degree of local atherosclerosis is alleviated after EF stimulation by local implantation of electrodes in the psoas major muscle in an atherosclerosis model in rabbits [ 11 ].
Here, we examined the inhibitory effects of DC EFs on neointimal hyperplasia and the lipari biochimica mechanism in an abdominal aorta balloon injury rabbit model.
Sixty rabbits 30 males and 30 females; 3 months old; 1.
The Exp lipari biochimica was then divided into 3. The abdominal aorta balloon injury model was established in the Con and the Exp groups.
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The electrodes were implanted in all rabbits, but only the Exp group received lipari biochimica stimulation. Samples were collected at 1, 2, and 4 weeks post-balloon injury in each group.
Materials Evans blue was purchased from Sigma-Aldrich St. Thus they nicely complement lipari biochimica main lectures.
As it is clear from the enclosed bibliography, the selected themes have received much attention in the scholarly literature that ranges from Nature to BMC Bioinformatics and Lipari biochimica.