Black Pepper- Piper Nigrum Benefits, Usage Dose Side Effects Botanical Name- Piper nigrum Linn. Black pepper – Medicinal Properties. Edibility Rating, *. Medicinal Rating, *. Other Uses Rating, *. Habit, Climber. Height, m. Self-fertile, Yes. Cultivation Status, Cultivated, Wild. Dried fruits of Piper nigrum (black pepper) are commonly used in gastrointestinal disorders. The aim of this study was to rationalize the medicinal use of pepper and its principal alkaloid, piperine, in constipation and diarrhea using in vitro and in vivo assays.
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Plants are important source of antioxidants. Some in vitro studies revealed that Piperine inhibited free radicals piper nigrum medicinal uses reactive oxygen species, therefore known to possess protective effects against oxidative damage.
Piper nigrum or piperine also found to decrease lipid peroxidation in vivo. Piper nigrum reported to possess antioxidant activity that might be due to the presence of flavonoids and phenolic contents. Piper nigrum was found to prevent the oxidative stress by inhibiting lipid piper nigrum medicinal uses, human lipoxygenase and arresting hydroxyl and superoxide free radicals, decrease lung carcinogenesis in animal studies.
The memoryenhancing and antioxidant proprieties of the methanolic extract of Piper nigrum L. The memory-enhancing effects of the extract were studied by means of in vivo Y-maze and radial arm-maze tasks approaches.
While, the antioxidant activity was evaluated by measuring activities of glutathione peroxidase, catalase, superoxide dismutase, and by measuring the total content of reduced glutathione, malondialdehyde, and protein carbonyl levels in the hippocampus.
The amyloid beta -treated rats showed the piper nigrum medicinal uses of spontaneous starvariation percentage piper nigrum medicinal uses Y- maze task and enhancement of work memory and reference memory errors within radial arm-maze task.
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Administration of the methanolic extract of Piper nigrum significantly improved memory performance and exhibited antioxidant potential. These studies suggest that methanolic extract of Piper nigrum ameliorates amyloid beta -induced spatial memory deterioration by depletion of the oxidative stress in the hippocampus of rats [ 17 ].
The antioxidant effect of three Piper species viz P. Animals were fed atherogenic diet addition with different piper nigrum medicinal uses of Piper species viz P.
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Piper species significantly inhibited the atherogenic diet induced increased lipid profile and alteration in antioxidant piper nigrum medicinal uses activities.
This study showed an antioxidant protective role of the extracts of Piper species against atherogenic diet induced oxidative stress in renal, cardiac and hepatic tissues [ 18].
Anti-cancer activity of black pepper: Piper nigrum had been reported to inhibit tumors formation in different experimental models. Many studied revealed the antitumor activity of P.
The alcoholic extract of peppercorn and piperine exhibited effective immunomodulatory and antitumor activities. Piperine is also reported to reduce the lung cancer by altering lipid peroxidation and by antioxidative protection enzymes activation [ 1 piper nigrum medicinal uses, 15 - 16 ].
Piperine has distinct pharmacological activities along with Anti-cancer activity. Piperine also inhibits the phosphorylation of Thr residues of Akt of protein kinase B as well as Ser Since phosphorylation of these is an essential controller of angiogenesis and function of endothelial cells.
Therefore, Piperine may beused as an inhibitor of piper nigrum medicinal uses angiogenesis for the treatment of cancer as angiogenesis plays a key role in the progression of tumor [ 19 ].
Docetaxel a cytotoxic chemotherapeutic agent is a FDA approved drug for the treatment for castration-resistant prostate cancer. Therefore, the administration of docetaxel in combination with piperine was investigated for both in vitro and in vivo pharmacokinetic activity of docetaxel.
It was also reported that nutritional use of piperine increased the efficacy of docetaxel in a xenograft model devoid of any side effects on the mice [ 20 ].
The anticancer activity of piperine against many cancer cell lines has been reported earlier. Therefore, the mechanisms of anticancer activity of piperine against piper nigrum medicinal uses androgen independent and dependent cells of prostate cancer were investigated.
Carcinogenicity testing of black pepper Piper nigrum using the Egyptian toad Bufo regularis as a quick biological test animal. Carcinogenic effect of force-feeding an extract of black pepper Piper nigrum in Egyptian toads Bufo regularis.
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