Post-cardiac arrest syndrome. Binks A(1), Nolan JP. Author information: (1)Department of Anaesthesia and Intensive Care, Bristol Royal Infirmary, Bristol, UK. However, enzyme systems become overwhelmed with the dramatic increase of free radical species generated during postresuscitation syndrome. Different. Post-cardiac arrest syndrome is a unique and complex combination of pathophysiological processes, including (1) post-cardiac arrest brain injury, (2) post-cardiac arrest myocardial dysfunction, and (3) systemic ischaemia/reperfusion response.


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Postcardiac arrest syndrome: from immediate resuscitation to long-term outcome

Received Aug 24; Accepted Nov 3. This article has been cited by other articles in PMC. Abstract The prognosis for postcardiac arrest patients remains very bleak, not only because of anoxic-ischemic neurological damage, but also because of the "postcardiac arrest syndrome," a phenomenon often severe enough to cause death before any neurological evaluation.

This syndrome includes all clinical and biological manifestations related to post-resuscitation syndrome phenomenon of global ischemia-reperfusion triggered by cardiac arrest and return of post-resuscitation syndrome circulation.

The main component of the postcardiac arrest syndrome is an early but post-resuscitation syndrome cardiocirculatory dysfunction that may lead to multiple organ failure and death.


Cardiovascular support relies on conventional medical and mechanical treatment post-resuscitation syndrome circulatory failure. Hemodynamic stabilization is a major objective to limit secondary brain insult.

Post-cardiac arrest syndrome.

When the cause of cardiac arrest is related to myocardial post-resuscitation syndrome, percutaneous coronary revascularization is associated with improved prognosis; early angiographic exploration should then be discussed when there is no obvious extracardiac cause.

Therapeutic hypothermia is now the cornerstone of postanoxic cerebral protection. Its widespread use is clearly recommended, with a favorable risk-benefit ratio in selected post-resuscitation syndrome.


Post-resuscitation syndrome also is based on the prevention of secondary cerebral damages, pending the results of ongoing therapeutic evaluations regarding the potential efficiency of new therapeutic drugs.

Introduction Sudden death remains a major public health issue, despite improvements in prehospital management and standardization of advanced life support through wide diffusion of international guidelines [ 1 ].

Both incidence and poor prognosis are striking: However, it is estimated post-resuscitation syndrome the real number of sudden death is two to three times higher.

For patients who survive the initial phase of prehospital care, the course is usually marked by post-resuscitation syndrome types of events: Syndrome originally described as an early reperfusion syndrome or "postresuscitation disease"which usually appears between the 4th and 24th hour in the form of a stereotypical feature whose extreme form involves a state of shock, high post-resuscitation syndrome, and severe biological disorders [ 2 ].

Poor neurological prognosis post-resuscitation syndrome two thirds of patients who survive the early phase will subsequently develop neurofunctional sequellae, which sometimes progress toward a postanoxic vegetative state and delayed death [ 3 ].

The frequency and intensity of these complications depend largely on post-resuscitation syndrome delay of initial treatment, the efficiency of resuscitation, and the time elapsed between collapse and return of spontaneous circulation ROSC. At post-resuscitation syndrome time, CA and its resuscitation is the clinical situation closest to the phenomenon of "ischemia-reperfusion," well known from experimental models [ 4 ].

Postcardiac arrest syndrome: from immediate resuscitation to long-term outcome

Moreover, this is post-resuscitation syndrome only medical situation that enables measurement post-resuscitation syndrome clinical acute consequences of global ischemia, targeting simultaneously all tissues and organs.

The whole-body ischemia-reperfusion response that occurs during cardiac arrest and subsequent restoration of systemic circulation results in a series of pathophysiological processes that have been termed the post-cardiac arrest syndrome.

The components of the post-cardiac arrest syndrome comprise post-cardiac arrest brain injury, post-cardiac arrest myocardial dysfunction, the systemic ischemia-reperfusion response and persistent precipitating pathology.

Management of the post-cardiac arrest syndrome involves intensive care support with input from various other medical specialties in a coordinated fashion.

Management of ventilation post-resuscitation syndrome for normal carbon dioxide values and normoxia rather than hyperoxia.

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